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具有氨基烷基的β(1,3)支化十七聚糖和直链十六聚糖是 dectin-1 的强配体。

β(1,3) Branched heptadeca- and linear hexadeca-saccharides possessing an aminoalkyl group as a strong ligand to dectin-1.

机构信息

Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1-H-101 Ookayama, Meguro, Tokyo, 152-8552, Japan.

出版信息

Chem Commun (Camb). 2010 Nov 21;46(43):8249-51. doi: 10.1039/c0cc03153d. Epub 2010 Oct 1.

DOI:10.1039/c0cc03153d
PMID:20890487
Abstract

In this report, we describe the convergent synthesis of β(1,3) oligosaccharides containing an aminoalkyl group. The branched heptadecasaccharide and linear hexadecasaccharide acted as ligands of dectin-1 whose binding affinity was only 10-fold weaker than that of natural SPG and exhibited dectin-1 agonist activity.

摘要

在本报告中，我们描述了含有氨基烷基的β(1,3)寡糖的汇聚合成。支化的十七聚糖和线性十六聚糖作为 dectin-1 的配体，其结合亲和力仅比天然 SPG 弱 10 倍，并表现出 dectin-1 激动剂活性。

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