Cano Carla E, Iovanna Juan L
INSERM U.624, Stress Cellulaire, Parc Scientifique et Technologique de Luminy, Marseille, France.
ScientificWorldJournal. 2010 Oct 1;10:1958-66. doi: 10.1100/tsw.2010.186.
Tumor metastasis is challenged by its resistance to microenvironmental stress infringed during escape from the primary tumor and the colonization of a foreign secondary tissue. Because of its great metastatic potential and its strong resistance to anticancer drugs, pancreatic cancer is regarded as a paradigm of the adaptation of cancer cells to microenvironmental stress. Thus, to understand how pancreatic cancer cells adapt to the different endogenous and therapy-related stresses is crucial for understanding their etiology and for the development of new efficient anticancer strategies. This review summarizes the multiple functions accomplished by one major factor of pancreatic cancer cell stress response, the stress protein p8.
肿瘤转移面临着挑战，因为它在逃离原发肿瘤并在异源继发组织中定植的过程中，对微环境应激具有抗性。由于其巨大的转移潜能和对抗癌药物的强大抗性，胰腺癌被视为癌细胞适应微环境应激的范例。因此，了解胰腺癌细胞如何适应不同的内源性和治疗相关应激，对于理解其病因以及开发新的高效抗癌策略至关重要。本综述总结了胰腺癌细胞应激反应的一个主要因素——应激蛋白p8所发挥的多种功能。
