Bruellhoff Kristina, Fiedler Jörg, Möller Martin, Groll Jürgen, Brenner Rolf E
DWI e.V. and Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany.
Int J Artif Organs. 2010 Sep;33(9):646-53. doi: 10.1177/039139881003300910.
Implant surfaces should ideally be designed to promote the attachment of target tissue cells; at the same time, they should prevent bacterial adhesion, achievable through modification strategies comprising three lines of defense. As the first criterion, selective adhesion can be realized by means of non-adhesive coatings that can be functionalized with small peptides, thereby supporting osteogenic cell attachment for implants in bone contact but not bacterial adhesion. The second line of defense, defined by bacterial survival, quorum sensing and biofilm formation, can be addressed by various antimicrobial substances that can be leaching or non-leaching. The possibility of a third line of defense, the disruption of an established biofilm, is just emerging. Since microorganisms are quite ''ingenious'' at finding ways to overcome a certain line of defense, the most promising solution might be a combination of all these antibacterial strategies. Coating systems that allow such different approaches to be combined are scarce. However, ultrathin multifunctional NCO-sP(EO-stat-PO)-based layers may represent a promising platform for such an integrated approach.
理想情况下，植入物表面的设计应促进目标组织细胞的附着；同时，应通过包含三道防线的改性策略来防止细菌粘附。作为首要标准，可通过用小肽进行功能化的非粘性涂层来实现选择性粘附，从而支持骨接触植入物的成骨细胞附着，但不支持细菌粘附。由细菌存活、群体感应和生物膜形成所定义的第二道防线，可通过各种可浸出或不可浸出的抗菌物质来应对。第三道防线，即破坏已形成的生物膜，刚刚崭露头角。由于微生物在找到克服某道防线的方法方面相当“聪明”，最有前景的解决方案可能是将所有这些抗菌策略结合起来。允许将这些不同方法结合起来的涂层系统很少。然而，基于超薄多功能NCO-sP(EO-stat-PO)的层可能是这种综合方法的一个有前景的平台。
