Krous Henry F, Langlois Neil E
University of California, San Diego School of Medicine, and San Diego SIDS/SUDC Research Project, Rady Children's Hospital-San Diego, 3020 Children’s Way, San Diego, CA 92123, USA.
Birth Defects Res A Clin Mol Teratol. 2010 Nov;88(11):947-52. doi: 10.1002/bdra.20728. Epub 2010 Oct 1.
Epidemiologic and experimental data support the notion that Ljungan virus (LV), endemic in some rodent populations in Sweden, Denmark, and the United States, can cause morbidity and mortality in animals and humans. LV infection can cause type I diabetes mellitus, myocarditis, and encephalitis in bank voles and experimental mice, and lemmings. Mouse dams infected with LV experience high rates of stillbirth that may persist across generations, and their fetuses may develop cranial, brain, and limb malformations. In humans, epidemiologic and serologic data suggest that LV infection correlates with intrauterine fetal death, malformations, placental inflammation, myocarditis, encephalitis, and Guillain-Barré syndrome. The proposed role of LV infection in SIDS is unconvincing. Further research is necessary to clarify the role of LV infection in animal and human disease.
流行病学和实验数据支持这样一种观点，即吕永病毒（LV）在瑞典、丹麦和美国的一些啮齿动物种群中流行，可导致动物和人类发病和死亡。LV感染可导致田鼠、实验小鼠和旅鼠患I型糖尿病、心肌炎和脑炎。感染LV的母鼠死胎率很高，且可能代代持续，其胎儿可能出现颅骨、脑部和肢体畸形。在人类中，流行病学和血清学数据表明，LV感染与宫内胎儿死亡、畸形、胎盘炎症、心肌炎、脑炎和格林-巴利综合征相关。LV感染在婴儿猝死综合征中所起的作用尚无说服力。有必要进行进一步研究以阐明LV感染在动物和人类疾病中的作用。
