心肌炎、胰岛素依赖型糖尿病和吉兰-巴雷综合征可能是由啮齿动物携带的一种或多种传染原引起的吗？
Could myocarditis, insulin-dependent diabetes mellitus, and Guillain-Barré syndrome be caused by one or more infectious agents carried by rodents?
作者信息
Niklasson B, Hörnfeldt B, Lundman B
机构信息
Swedish Institute for Infectious Disease Control, Stockholm, Sweden.
出版信息
Emerg Infect Dis. 1998 Apr-Jun;4(2):187-93. doi: 10.3201/eid0402.980206.
Abstract
The numbers of small rodents in northern Sweden fluctuate heavily, peaking every 3 or 4 years. We found that the incidence of Guillain-Barré syndrome and insulin-dependent diabetes mellitus, as well as the number of deaths caused by myocarditis, followed the fluctuations in numbers of bank voles, although with different time lags. An environmental factor, such as an infectious agent, has been suggested for all three diseases. We hypothesize that Guillain-Barré syndrome, myocarditis, and insulin-dependent diabetes mellitus in humans in Sweden are caused by one or more infectious agents carried by small rodents. Also, a group of novel picornaviruses recently isolated from these small rodents is being investigated as the possible etiologic agent(s).
摘要
瑞典北部小型啮齿动物的数量波动剧烈，每3到4年达到峰值。我们发现，格林-巴利综合征和胰岛素依赖型糖尿病的发病率以及心肌炎导致的死亡人数，都随着田鼠数量的波动而变化，不过存在不同的时间滞后。对于这三种疾病，都有人提出存在一种环境因素，比如感染源。我们推测，瑞典人类中的格林-巴利综合征、心肌炎和胰岛素依赖型糖尿病是由小型啮齿动物携带的一种或多种感染源引起的。此外，最近从这些小型啮齿动物中分离出的一组新型微小核糖核酸病毒正在作为可能的病原体进行研究。
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