泰勒氏小鼠脑脊髓炎病毒TO株的特性分析
Characterization of the TO strains of Theiler's mouse encephalomyelitis viruses.
作者信息
Lipton H L
出版信息
Infect Immun. 1978 Jun;20(3):869-72. doi: 10.1128/iai.20.3.869-872.1978.
Abstract
Theiler's mouse encephalomyelitis virus isolates from the central nervous systems of spontaneously paralyzed mice and stools of asymptomatic mice resemble Theiler's original virus isolates. In this study four such strains were adapted by blind subpassage to replicate and to produce cytopathic effect in cell culture. These viruses were then found to be closely related to each other and to GDVII virus by cross-neutralization and to form small plaques. Bovine serum was found to contain cross-reacting antibodies to these viruses.
摘要
从自发瘫痪小鼠的中枢神经系统和无症状小鼠的粪便中分离出的泰勒氏小鼠脑脊髓炎病毒与泰勒氏最初分离出的病毒相似。在本研究中，通过盲目传代使4株这样的病毒适应在细胞培养中复制并产生细胞病变效应。然后通过交叉中和发现这些病毒彼此密切相关且与GDVII病毒密切相关，并形成小斑块。发现牛血清中含有针对这些病毒的交叉反应抗体。
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