仔猪心肺复苏后血脑屏障破坏

Blood-brain barrier disruption following CPR in piglets.

作者信息

Schleien C L, Koehler R C, Shaffner D H, Traystman R J

机构信息

Johns Hopkins Medical Institutions, Department of Anesthesiology/Critical Care Medicine, Baltimore, Maryland.

出版信息

Acta Neurochir Suppl (Wien). 1990;51:213-5. doi: 10.1007/978-3-7091-9115-6_72.

DOI:10.1007/978-3-7091-9115-6_72

PMID:2089897

Abstract

We studied blood-brain barrier (BBB) integrity in immature piglets during the following cardiopulmonary resuscitation (CPR). As in our previous work in the dog, there was no disruption during CPR after eight minutes of cardiac arrest, or immediately following resuscitation using a small molecule, alpha-aminoisobutyric acid. However, unlike the dog, where the BBB remained intact, we found delayed disruption of the BBB four hours after resuscitation. Young animals may be more prone to a delayed increase in BBB permeability after cardiac arrest and CPR.

摘要

我们研究了未成熟仔猪在后续心肺复苏（CPR）过程中的血脑屏障（BBB）完整性。正如我们之前在狗身上所做的研究一样，心脏骤停8分钟后进行CPR期间，或使用小分子α-氨基异丁酸复苏后即刻，血脑屏障均未受到破坏。然而，与血脑屏障保持完整的狗不同，我们发现复苏后4小时血脑屏障出现延迟性破坏。幼龄动物在心脏骤停和CPR后可能更容易出现血脑屏障通透性的延迟增加。