Corner A M, Brightman V J, Cooper S, Yankell S L, Malamud D
University of Pennsylvania School of Dental Medicine.
J Clin Dent. 1990 Fall;2(2):34-8.
In vitro studies have demonstrated the antiplaque properties of C31G, a potent broad spectrum antimicrobial agent consisting of an equimolar mixture of alkyl dimethyl glycine and alkyl dimethyl amine oxide, buffered with citric acid. In this initial clinical study, C31G at concentrations of 0.05%, 0.1%, 0.2% and 0.5%. Listerine, and placebo were tested in a complete crossover design. Twelve subjects were evaluated, with a minimum of 2 days between treatments. Parameters monitored were salivary bacterial counts and saliva glycolysis. The 0.5% and 0.2% C31G mouthrinses significantly reduced total bacterial counts in saliva samples obtained up to and including three hours after rinsing, compared with counts obtained prerinsing or after placebo rinsing. Both 0.5%, and 0.2% C31G significantly inhibited glycolysis of salivary bacteria for up to 6 hours postrinsing, compared with pH values obtained prerinsing. 0.1% and 0.05% C31G exhibited little or no effect in either assay. Listerine showed a significant reduction in bacterial counts for up to 1 hour postrinsing, compared with prerinse counts, but the effect was less sustained. Listerine showed no significant inhibition of glycolysis at any time point. No tooth staining or altered taste sensation was noted with either product.
体外研究已证实C31G具有抗牙菌斑特性。C31G是一种强效广谱抗菌剂，由烷基二甲基甘氨酸和烷基二甲基氧化胺的等摩尔混合物组成，并用柠檬酸缓冲。在这项初步临床研究中，对浓度为0.05%、0.1%、0.2%和0.5%的C31G、李施德林漱口水和安慰剂进行了完全交叉设计测试。评估了12名受试者，每次治疗间隔至少2天。监测的参数为唾液细菌计数和唾液糖酵解。与冲洗前或安慰剂冲洗后获得的计数相比，0.5%和0.2%的C31G漱口水在冲洗后直至包括3小时内采集的唾液样本中显著降低了总细菌计数。与冲洗前获得的pH值相比，0.5%和0.2%的C31G在冲洗后长达6小时内均显著抑制了唾液细菌的糖酵解。0.1%和0.05%的C31G在两种检测中均显示出很少或没有效果。与冲洗前的计数相比，李施德林漱口水在冲洗后长达1小时内细菌计数显著降低，但效果持续时间较短且在任何时间点均未显示出对糖酵解的显著抑制作用。两种产品均未观察到牙齿染色或味觉改变。
