Wimmer M, Luttringer C, Colombi M
Anatomisches Institut, Universität Basel.
Biol Chem Hoppe Seyler. 1990 Dec;371(12):1129-35. doi: 10.1515/bchm3.1990.371.2.1129.
The effects of the administration of insulin and glucagon on the intraacinar heterotopy of phosphoenolpyruvate carboxykinase (PEPCK) were investigated in male and female rat liver. Insulin did not noticeably influence PEPCK activity or its acinar distribution, either in males or in females. But it affected the activities of glucose-6-phosphate dehydrogenase and malic enzyme. Glucagon in supraphysiological concentrations led to an induction of PEPCK activity. Despite high glucagon concentration along the whole sinusoidal length, the inducing effect of glucagon was most pronounced in the periportal and intermediary parts of the acinus; thus indicating that there is no direct interrelationship between local glucagon concentration and PEPCK activity. In both experiments blood glucose levels were kept fairly constant.
研究了胰岛素和胰高血糖素对雄性和雌性大鼠肝脏腺泡内磷酸烯醇丙酮酸羧激酶（PEPCK）异位的影响。胰岛素对雄性或雌性大鼠的PEPCK活性及其腺泡分布均无明显影响。但它影响了葡萄糖-6-磷酸脱氢酶和苹果酸酶的活性。超生理浓度的胰高血糖素导致PEPCK活性诱导。尽管沿整个窦状隙长度胰高血糖素浓度都很高，但胰高血糖素的诱导作用在腺泡的门静脉周围和中间部分最为明显；因此表明局部胰高血糖素浓度与PEPCK活性之间没有直接的相互关系。在两个实验中，血糖水平都保持相当稳定。
