Sasco A J, Paffenbarger R S
Harvard University School of Public Health, Boston.
Epidemiology. 1990 Nov;1(6):460-5.
A case-control analysis of Parkinson's disease and smoking habits was conducted in a cohort of 50,002 men who attended Harvard College (Cambridge, MA) or the University of Pennsylvania (Philadelphia, PA) between 1916 and 1950 and were followed in adulthood for morbidity and mortality data. Ninety-six cases of Parkinson's disease were identified from responses to a mailed questionnaire, addressed in 1976 to the University of Pennsylvania alumni and in 1977-1978 to the Harvard alumni. Four controls from the same population were selected for each case. Even though no statistically significant association was found, the results support a negative association between cigarette smoking and Parkinson's disease.
对1916年至1950年间就读于哈佛学院（马萨诸塞州剑桥）或宾夕法尼亚大学（宾夕法尼亚州费城）的50,002名男性队列进行了帕金森病与吸烟习惯的病例对照分析，并在成年后对其发病率和死亡率数据进行跟踪。通过对1976年发给宾夕法尼亚大学校友以及1977 - 1978年发给哈佛大学校友的邮寄问卷的回复，确定了96例帕金森病病例。为每个病例从同一人群中选取4名对照。尽管未发现统计学上的显著关联，但结果支持吸烟与帕金森病之间存在负相关。
