Wijnands W J, Vree T B, Baars A M, van Herwaarden C L
Department of Pulmonary Diseases, Medical Centre Dekkerswald, Nijmegen, The Netherlands.
Pharm Weekbl Sci. 1987 Dec 11;9 Suppl:S72-5. doi: 10.1007/BF02075266.
Pharmacokinetic parameters of the bronchodilator theophylline were assessed in eight patients with chronic obstructive lung disease when administered alone and when comedicated with ciprofloxacin 500 mg twice daily, ofloxacin 400 mg twice daily, or pefloxacin 400 mg twice daily. Compared to the control period, in which only theophylline was administered, the total body clearance of theophylline decreased significantly during ciprofloxacin (30.4%) and pefloxacin (29.4%) coadministration, whereas no change of the renal clearance of theophylline occurred. Ofloxacin did not influence the pharmacokinetic parameters of theophylline. From these observations it is concluded that ciprofloxacin and pefloxacin reduce the metabolic clearance of theophylline.
在8例慢性阻塞性肺疾病患者中，评估了支气管扩张剂茶碱单独给药时以及与环丙沙星（每日2次，每次500mg）、氧氟沙星（每日2次，每次400mg）或培氟沙星（每日2次，每次400mg）合用时的药代动力学参数。与仅给予茶碱的对照期相比，在与环丙沙星（30.4%）和培氟沙星（29.4%）合用时，茶碱的总体清除率显著降低，而茶碱的肾清除率未发生变化。氧氟沙星不影响茶碱的药代动力学参数。从这些观察结果得出结论，环丙沙星和培氟沙星降低了茶碱的代谢清除率。
