尿卟啉原筛查试验的可靠性。
Reliability of the porphobilinogen screening assay.
作者信息
Buttery J E, Carrera A M, Pannall P R
机构信息
Department of Clinical Chemistry, Queen Elizabeth Hospital, South Australia.
出版信息
Pathology. 1990 Oct;22(4):197-8. doi: 10.3109/00313029009086660.
A survey conducted by the Australian Association of Clinical Biochemists Porphyrin Working Party on urinary porphobilinogen screening showed good sensitivity (75-97.5%). This is contrary to reports in the literature and to our own observations. We therefore assessed a widely used screening method (Watson-Schwartz) and found poor sensitivity (40-69%), and even less sensitivity (28-53%) when the urine samples were normally coloured or concentrated. Thus the results obtained by the Working Party might mislead one to infer that the Watson-Schwartz method is reliable.
澳大利亚临床生物化学家协会卟啉工作组开展的一项关于尿卟胆原筛查的调查显示出良好的敏感性（75 - 97.5%）。这与文献报道以及我们自己的观察结果相悖。因此，我们评估了一种广泛使用的筛查方法（沃森 - 施瓦茨法），发现其敏感性较差（40 - 69%），当尿样颜色正常或浓缩时敏感性甚至更低（28 - 53%）。所以，工作组获得的结果可能会误导人们推断沃森 - 施瓦茨法是可靠的。
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