血浆中肾上腺素和去甲肾上腺素的灵敏放射酶测定法。
A sensitive radioenzymatic assay for adrenaline and noradrenaline in plasma.
作者信息
Hörtnagl H, Benedict C R, Grahame-Smith D G
出版信息
Br J Clin Pharmacol. 1977 Oct;4(5):553-8. doi: 10.1111/j.1365-2125.1977.tb00785.x.
Abstract
1 An existing radioenzymatic assay for plasma catecholamines using catechol-o-methyl transferase and [3H]-S-adenosyl-methionine has been modified resulting in a more sensitive assay for the measurement of plasma adrenaline and noradrenaline. 2 The lower limit of sensitivity for this method is 25 pg for adrenaline and 30 pg for noradrenaline/ml of plasma. 3 Resting supine (60 min) plasma adrenaline concentration was (mean +/- s.d.) 124 +/- 76 pg/ml(n=11) in males and 130 +/- 71 pg/ml (n=7) in females; plasma noradrenaline concentrations were respectively 444 +/- 129 pg/ml and 550 +/- 87 pg/ml. 4 The changes in plasma catecholamine concentrations in response to 40 degrees head-up tilt have been determined in a group of healthy normal subjects and have been shown to be related to changes in blood pressure and heart rate.
摘要
- 一种现有的利用儿茶酚 - O - 甲基转移酶和[3H] - S - 腺苷甲硫氨酸测定血浆儿茶酚胺的放射酶法已被改进，从而得到一种更灵敏的测定血浆肾上腺素和去甲肾上腺素的方法。2. 该方法的灵敏度下限为血浆中肾上腺素25皮克/毫升，去甲肾上腺素30皮克/毫升。3. 静息仰卧（60分钟）时，男性血浆肾上腺素浓度为（均值±标准差）124±76皮克/毫升（n = 11），女性为130±71皮克/毫升（n = 7）；血浆去甲肾上腺素浓度分别为444±129皮克/毫升和550±87皮克/毫升。4. 已在一组健康正常受试者中测定了40度头高位倾斜后血浆儿茶酚胺浓度的变化，并表明其与血压和心率的变化有关。
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