作为释放率指标的血浆去甲肾上腺素浓度变化。
Changes in plasma noradrenaline concentration as a measure of release rate.
作者信息
Benedict C R, Fillenz M, Stanford C
出版信息
Br J Pharmacol. 1978 Oct;64(2):305-9. doi: 10.1111/j.1476-5381.1978.tb17305.x.
Abstract
1 A method is described for repeated sampling of plasma noradrenaline (NA) in freely moving rats. Na concentration does not change during the day or after adrenalectomy. 2 Exogenous NA has a half-life of 1.5 min; drugs which block neuronal and extra-neuronal uptake lengthen this to 6.3 min. 3 Swim-stress leads to a steep rise followed by a rapid decline in plasma NA concentration. 4 This method of plasma NA sampling can serve as a measure of both steady and rapid changes in release rate over long periods of time.
摘要
- 本文描述了一种对自由活动大鼠血浆去甲肾上腺素（NA）进行重复采样的方法。去甲肾上腺素浓度在白天或肾上腺切除术后不会发生变化。2. 外源性去甲肾上腺素的半衰期为1.5分钟；阻断神经元和非神经元摄取的药物可将其延长至6.3分钟。3. 游泳应激导致血浆去甲肾上腺素浓度急剧上升，随后迅速下降。4. 这种血浆去甲肾上腺素采样方法可作为长时间内释放速率稳定和快速变化的一种测量方法。
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