Steen G, Weber R F
Department of Clinical Chemistry, University Hospital Rotterdam-Dijkzigt, The Netherlands.
Diabetes Res. 1990 Apr;13(4):177-82.
The therapy of 10 patients with insulin-dependent diabetes mellitus was changed from insulin twice a day to the use of insulin pens four times a day. The possible changes in glycaemic control were monitored by day curves once a week and analysis of fructosamine and glycated haemoglobin once a fortnight. No significant changes in these parameters were seen. However, a significant decrease in the number of hypoglycaemic periods does point to an improvement of therapy. One patient having elevated values of glucose and glycated haemoglobin but "normal" concentrations of fructosamine prompted us to analyze in detail the influence of protein and albumin on fructosamine. Correction of fructosamine for low protein or albumin increases the value of this test.
10例胰岛素依赖型糖尿病患者的治疗方案从每日两次胰岛素注射改为每日四次使用胰岛素笔。每周通过日间血糖曲线监测血糖控制的可能变化，每两周分析一次果糖胺和糖化血红蛋白。这些参数未见显著变化。然而，低血糖发作次数的显著减少确实表明治疗有所改善。一名患者血糖和糖化血红蛋白值升高，但果糖胺浓度“正常”，这促使我们详细分析蛋白质和白蛋白对果糖胺的影响。针对低蛋白或低白蛋白情况校正果糖胺会提高该检测值。
