Murphy John L, Vollenweider Laura, Xu Fangmin, Lee Bruce P
Nerites Corporation, Madison, Wisconsin 53719, United States.
Biomacromolecules. 2010 Nov 8;11(11):2976-84. doi: 10.1021/bm1007794. Epub 2010 Oct 4.
Surgical repair of a discontinuity in traumatized or degenerated soft tissues is traditionally accomplished using sutures. A current trend is to reinforce this primary repair with surgical grafts, meshes, or patches secured with perforating mechanical devices (i.e., sutures, staples, or tacks). These fixation methods frequently lead to chronic pain and mesh detachment. We developed a series of biodegradable adhesive polymers that are synthetic mimics of mussel adhesive proteins (MAPs), composed of 3,4-dihydroxyphenylalanine (DOPA)-derivatives, polyethylene glycol (PEG), and polycaprolactone (PCL). These polymers can be cast into films, and their mechanical properties, extent of swelling, and degradation rate can be tailored through the composition of the polymers as well as blending with additives. When coated onto a biologic mesh used for hernia repair, these adhesive constructs demonstrated adhesive strengths significantly higher than fibrin glue. With further development, a precoated bioadhesive mesh may represent a new surgical option for soft tissue repair.
传统上，使用缝线来完成对受创伤或退化的软组织连续性的手术修复。当前的趋势是用手术移植物、网片或贴片，通过穿孔机械装置（即缝线、吻合钉或大头钉）固定来加强这种初次修复。这些固定方法常常导致慢性疼痛和网片脱离。我们研发了一系列可生物降解的粘性聚合物，它们是贻贝粘附蛋白（MAPs）的合成模拟物，由3,4 - 二羟基苯丙氨酸（DOPA）衍生物、聚乙二醇（PEG）和聚己内酯（PCL）组成。这些聚合物可以制成薄膜，其机械性能、膨胀程度和降解速率可以通过聚合物的组成以及与添加剂混合来调整。当涂覆在用于疝气修复的生物网片上时，这些粘附结构表现出显著高于纤维蛋白胶的粘附强度。随着进一步发展，预涂覆的生物粘附网片可能代表软组织修复的一种新的手术选择。
