Ge Liangpeng, Chen Shixuan
Chongqing Academy of Animal Sciences and Key Laboratory of Pig Industry Sciences, Ministry of Agriculture, Chongqing 402460, China.
Department of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68105, USA.
Polymers (Basel). 2020 Apr 18;12(4):939. doi: 10.3390/polym12040939.
Tissue adhesives have attracted more attention to the applications of non-invasive wound closure. The purpose of this review article is to summarize the recent progress of developing tissue adhesives, which may inspire researchers to develop more outstanding tissue adhesives. It begins with a brief introduction to the emerging potential use of tissue adhesives in the clinic. Next, several critical mechanisms for adhesion are discussed, including van der Waals forces, capillary forces, hydrogen bonding, static electric forces, and chemical bonds. This article further details the measurement methods of adhesion and highlights the different types of adhesive, including natural or biological, synthetic and semisynthetic, and biomimetic adhesives. Finally, this review article concludes with remarks on the challenges and future directions for design, fabrication, and application of tissue adhesives in the clinic. This review article has promising potential to provide novel creative design principles for the generation of future tissue adhesives.
组织粘合剂在无创伤口闭合应用方面已引起更多关注。这篇综述文章的目的是总结开发组织粘合剂的最新进展，这可能会激励研究人员开发出更出色的组织粘合剂。文章首先简要介绍了组织粘合剂在临床上新兴的潜在用途。接下来，讨论了几种关键的粘附机制，包括范德华力、毛细作用力、氢键、静电力和化学键。本文进一步详细介绍了粘附力的测量方法，并重点介绍了不同类型的粘合剂，包括天然或生物粘合剂、合成和半合成粘合剂以及仿生粘合剂。最后，这篇综述文章总结了组织粘合剂在临床设计、制造和应用方面面临的挑战以及未来方向。这篇综述文章有潜力为未来组织粘合剂的生成提供新颖的创新设计原则。
