Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Drive, Winnipeg MB, R3T 2N2, Canada.
Nutr Metab (Lond). 2010 Sep 28;7:76. doi: 10.1186/1743-7075-7-76.
As hyperlipidemia, including hypercholesterolemia (HC) and hypertriglyceridemia (HTN), continue to challenge North America's healthcare systems, patients continue to seek efficacious and safe natural therapies that complement pharmaceutical interventions. However, despite the ever-growing body of research supporting the use of functional foods and nutraceuticals (FFN) for the prevention and treatment of hyperlipidemia, reception amongst the medical community regarding the implementation of FFN into clinical guidelines continues to lag. Research demonstrates that specific FFN target and modulate molecular processes that perpetuate hyperlipidemia. In addition, studies consistently demonstrate that combining certain FFN such as marine-derived omega-3 fatty acids or plant sterols/stanols with statins enhances triglyceride and cholesterol-lowering efficacy, respectively. Thus, the purpose of this commentary is to contend that efficacious FFN not only reduce HC and HTG but also boost the lipid-lowering effects of pharmaceutical hypolipidemic medications. Finally, this editorial aims to challenge current medical guidelines to emphasize efficacious FFN during all stages of treatment of hyperlipidemias as adjuncts to pharmacotherapy.
随着高血脂症（包括高胆固醇血症[HC]和高甘油三酯血症[HTN]）继续给北美医疗系统带来挑战，患者仍在寻求有效且安全的天然疗法来辅助药物干预。然而，尽管越来越多的研究支持使用功能性食品和营养保健品（FFN）来预防和治疗高血脂症，但医学界在将 FFN 纳入临床指南方面的接受程度仍然滞后。研究表明，特定的 FFN 可靶向并调节持续高血脂症的分子过程。此外，研究一致表明，将某些 FFN（如海洋衍生的 omega-3 脂肪酸或植物甾醇/甾烷醇）与他汀类药物联合使用，可分别增强降低甘油三酯和胆固醇的效果。因此，本评论的目的是认为有效的 FFN 不仅可以降低 HC 和 HTG，还可以增强降脂药物的降脂效果。最后，本社论旨在挑战当前的医学指南，强调在高血脂症治疗的所有阶段都要使用有效的 FFN 作为药物治疗的辅助手段。
