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健康个体中多不饱和脂肪酸水平与血脂之间的关联。

Association between the levels of polyunsaturated fatty acids and blood lipids in healthy individuals.

作者信息

Wang Si-Ping, Chen Yan-Hong, Li Hong

机构信息

Department of Special Service of the Chinese PLA General Hospital, Beijing 100853, P.R. China.

出版信息

Exp Ther Med. 2012 Dec;4(6):1107-1111. doi: 10.3892/etm.2012.724. Epub 2012 Sep 26.

Abstract

The levels of polyunsaturated fatty acids (PUFAs) in blood is closely associated with the status of the health of individuals; in particular, the lack of ω-3 fatty acids may lead to the development of numerous diseases. The aim of this study was to investigate the levels of PUFAs, and their correlation with triglycerides and other factors in blood. The levels of PUFAs and blood lipids were detected in 156 healthy individuals; the blood samples were tested by combined thin-layer and gas liquid chromatographic analysis. The level of ω-3 fatty acids was low in the subjects and the ω-3 index was 4.25%, while the ω-6:ω-3 ratio was at a satisfactory level. There was a strong inverse correlation between ω-3 fatty acids and triglycerides, and a strong positive correlation between ω-3 fatty acids and high density lipoprotein (HDL). Eicosapentaenoic acid and docosahexaenoic acid were inversely correlated with triglycerides, and positively correlated with HDL. In conclusion, ω-3 fatty acids are able to adjust the levels of blood lipids, and lower the levels of triglycerides, which may contribute to human health.

摘要

血液中多不饱和脂肪酸(PUFAs)的水平与个体健康状况密切相关;特别是,ω-3脂肪酸的缺乏可能导致多种疾病的发生。本研究的目的是调查PUFAs的水平及其与血液中甘油三酯和其他因素的相关性。对156名健康个体的PUFAs水平和血脂进行了检测;血液样本通过薄层色谱和气相色谱联用分析进行检测。受试者的ω-3脂肪酸水平较低,ω-3指数为4.25%,而ω-6:ω-3比值处于令人满意的水平。ω-3脂肪酸与甘油三酯呈强负相关,与高密度脂蛋白(HDL)呈强正相关。二十碳五烯酸和二十二碳六烯酸与甘油三酯呈负相关,与HDL呈正相关。总之,ω-3脂肪酸能够调节血脂水平,降低甘油三酯水平,这可能对人类健康有益。

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