Department of Rheumatology, Sorlandet Hospital, Kristiansand, Servicebox 416, 4604 Kristiansand, Norway.
BMC Musculoskelet Disord. 2010 Sep 29;11:226. doi: 10.1186/1471-2474-11-226.
The long-term effect of hip fracture on health-related quality of life (HRQOL) and global quality of life (GQOL) has not been thoroughly studied in prospective case-control studies.
a) to explore whether patients with low-energy hip fracture regain their pre-fracture levels in HRQOL and GQOL compared with changes in age- and sex-matched controls over a two year period; b) to identify predictors of changes in HRQOL and GQOL after two years.
We examined 61 patients (mean age = 74 years, SD = 10) and 61 matched controls (mean age = 73 years, SD = 8). The Short Form 36 assessed HRQOL and the Quality of Life Scale assessed GQOL. Paired samples t tests and multiple linear regression analyses were applied.
HRQOL decreased significantly between baseline and one-year follow-up in patients with hip fractures, within all the SF-36 domains (p < 0.04), except for social functioning (p = 0.091). There were no significant decreases within the SF-36 domains in the controls. Significantly decreased GQOL scores (p < 0.001) were observed both within patients and within controls between baseline and one-year follow-up. The same pattern persisted between baseline and two-year follow-up, except for the HRQOL domain mental health (p = 0.193). The patients with hip fractures did not regain their HRQOL and GQOL. Worsened physical health after two years was predicted by being a patient with hip fracture (B = -5.8, p < 0.001) and old age (B = -1.0, p = 0.015), while worsened mental health was predicted by co-morbidity (B = -2.2, p = 0.029). No significant predictors of differential changes in GQOL were identified.
A hip fracture has a long-term impact on HRQOL and is a strong predictor of worsened physical health. Our data emphasize the importance of preventing hip fracture in the elderly to maintain physical health. This knowledge should be included in decision-making and health care plans.
在前瞻性病例对照研究中,髋部骨折对健康相关生活质量(HRQOL)和整体生活质量(GQOL)的长期影响尚未得到充分研究。
a)探讨在两年内,与年龄和性别匹配的对照组相比,低能量髋部骨折患者在 HRQOL 和 GQOL 方面是否恢复到骨折前的水平;b)确定两年后 HRQOL 和 GQOL 变化的预测因素。
我们检查了 61 名患者(平均年龄=74 岁,标准差=10)和 61 名匹配的对照组(平均年龄=73 岁,标准差=8)。采用 36 项简短健康调查量表评估 HRQOL,采用生活质量量表评估 GQOL。采用配对样本 t 检验和多元线性回归分析。
髋部骨折患者在基线和一年随访时,除社会功能外(p=0.091),所有 SF-36 领域的 HRQOL 均显著下降(p<0.04)。对照组的 SF-36 领域内没有明显的下降。患者和对照组在基线和一年随访时,GQOL 评分均显著下降(p<0.001)。这种模式在基线和两年随访时持续存在,除了心理健康 HRQOL 领域(p=0.193)。髋部骨折患者并未恢复其 HRQOL 和 GQOL。两年后,身体状况恶化的预测因素是髋部骨折患者(B=-5.8,p<0.001)和高龄(B=-1.0,p=0.015),而心理健康恶化的预测因素是合并症(B=-2.2,p=0.029)。未确定 GQOL 差异变化的显著预测因素。
髋部骨折对 HRQOL 有长期影响,是身体状况恶化的有力预测因素。我们的数据强调了预防老年人髋部骨折以维持身体健康的重要性。这一知识应该纳入决策和医疗保健计划中。