Pande I, Scott D L, O'Neill T W, Pritchard C, Woolf A D, Davis M J
Department of Rheumatology, City Hospital, Nottingham, UK.
Ann Rheum Dis. 2006 Jan;65(1):87-92. doi: 10.1136/ard.2004.034611. Epub 2005 Aug 3.
Osteoporotic hip fractures have been extensively studied in women, but they have been relatively ignored in men.
To study the mortality, morbidity, and impact on health related quality of life of male hip fractures.
100 consecutive men aged 50 years and over, with incident low trauma hip fracture, admitted to Royal Cornwall Hospital, UK during 1995-97, were studied. 100 controls were recruited from a nearby general practice. Mortality and morbidity, including health status assessed using the SF-36, were evaluated over a 2 year follow up period.
Survival after 2 years was 37% in fracture cases compared with 88% in controls (log rank test 62.6, df = 1, p = 0.0001). In the first year 45 patients died but only one control. By 2 years 58 patients but only 8 controls had died. Patients with hip fracture died from various causes, the most common being bronchopneumonia (21 cases), heart failure (9 cases), and ischaemic heart disease (8 cases). Factors associated with increased mortality after hip fracture included older age, residence before fracture in a nursing or residential home, presence of comorbid diseases, and poor functional activity before fracture. Patients with fracture were often disabled with poor quality of life. By 24 months 7 patients could not walk, 12 required residential accommodation, and the mean SF-36 physical summary score was 1.7SD below the normal standards.
Low trauma hip fracture in men is associated with a significant increase in mortality and morbidity. Impaired function before fracture is a key determinant of mortality after fracture.
骨质疏松性髋部骨折在女性中已得到广泛研究,但在男性中相对被忽视。
研究男性髋部骨折的死亡率、发病率以及对健康相关生活质量的影响。
对1995年至1997年期间入住英国皇家康沃尔医院的100例年龄在50岁及以上、发生低创伤性髋部骨折的连续男性患者进行研究。从附近的普通诊所招募了100名对照者。在2年的随访期内评估死亡率和发病率,包括使用SF-36评估的健康状况。
骨折病例2年后的生存率为37%,而对照组为88%(对数秩检验62.6,自由度=1,p=0.0001)。第一年有45例患者死亡,但对照组仅1例。到2年时,有58例患者死亡,而对照组仅8例。髋部骨折患者死于各种原因,最常见的是支气管肺炎(21例)、心力衰竭(9例)和缺血性心脏病(8例)。髋部骨折后死亡率增加的相关因素包括年龄较大、骨折前居住在养老院或疗养院、存在合并症以及骨折前功能活动较差。骨折患者常因生活质量差而致残。到24个月时,7例患者无法行走,12例需要入住养老院,SF-36身体综合评分平均比正常标准低1.7个标准差。
男性低创伤性髋部骨折与死亡率和发病率显著增加相关。骨折前功能受损是骨折后死亡率的关键决定因素。