从木荷茎中分离得到的两种新型8-O-4'-型木脂素及其对人癌细胞系的细胞生长抑制活性。

Two new 8-O-4'-type lignans from the stem of Schima superba and their cell growth inhibitory activities against human cancer cell lines.

作者信息

Xu Wen, Wang Hui, Zhou Guang-Xiong, Yao Xin-Sheng

机构信息

Institute of Traditional Chinese Medicine & Natural Products, Guangdong Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, China.

出版信息

J Asian Nat Prod Res. 2010 Oct;12(10):874-8. doi: 10.1080/10286020.2010.508036.

DOI:10.1080/10286020.2010.508036

PMID:20924901

Abstract

Two new lignans (1 and 2) were isolated from the EtOH extracts of the stem of Schima superba, and elucidated as (7R,8S)-1-(3,4-dimethoxyphenyl)-2-O-(2-methoxy-4-omegahydroxypropylphenyl)propane-1,3-diol (1) and threo-1-(4-hydroxy-3-methoxyphenyl)-1-methoxy-2-{4-[1-formyl-(E)-vinyl]-2-methoxyphenoxy}-3-propanol (2) by spectral analysis. Compounds 1 and 2 showed cell growth inhibitory activity against HeLa, CNE, HepG-2, and HEp-2 cell lines. Compound 1 exhibited significant cytotoxicities with IC₅₀ values of less than 4 μg/ml against all the tested cell lines.

摘要

从木荷茎的乙醇提取物中分离出两种新的木脂素（1和2），通过光谱分析鉴定为(7R,8S)-1-(3,4-二甲氧基苯基)-2-O-(2-甲氧基-4-ω-羟基丙基苯基)丙烷-1,3-二醇（1）和苏式-1-(4-羟基-3-甲氧基苯基)-1-甲氧基-2-{4-[1-甲酰基-(E)-乙烯基]-2-甲氧基苯氧基}-3-丙醇（2）。化合物1和2对HeLa、CNE、HepG-2和HEp-2细胞系显示出细胞生长抑制活性。化合物1对所有测试细胞系均表现出显著的细胞毒性，IC₅₀值小于4μg/ml。