Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
J Nat Prod. 2010 Apr 23;73(4):632-8. doi: 10.1021/np900795c.
Thirteen new iridoids including seven iridolactones, jatamanins A-M (1-13), and a new lignan, (+)-9'-isovaleroxylariciresinol (14), together with seven known iridoids and 13 lignans were obtained from whole plants of Valeriana jatamansi. Structures of the new compounds were determined by spectroscopic and crystallographic methods, and the absolute configuration of compound 1 was assigned by application of the modified Mosher method. Jatamanins H (8) and I (9) are iridolactones with an unusual C-8-C-11 oxygen bridge, forming a cage-like structure. (+)-9'-Isovaleroxylariciresinol (14) showed significant in vitro cytotoxicity against PC-3M and HCT-8 cell lines, with IC(50) values of 8.1 and 5.3 microM, respectively.
从缬草中分离得到 13 个新的环烯醚萜类化合物，包括 7 个环烯醚萜内酯， jatamanins A-M（1-13），和一个新的木脂素，（+）-9'-异戊酰基紫铆因（14），以及 7 个已知的环烯醚萜和 13 个木脂素。新化合物的结构通过光谱和晶体学方法确定，化合物 1 的绝对构型通过应用改良的 Mosher 方法确定。jatamanins H（8）和 I（9）是具有不寻常的 C-8-C-11 氧桥的环烯醚萜内酯，形成笼状结构。（+）-9'-异戊酰基紫铆因（14）对 PC-3M 和 HCT-8 细胞系表现出显著的体外细胞毒性，IC50 值分别为 8.1 和 5.3 μM。
