Unit of General Practice, Helsinki University Central Hospital, University of Helsinki, PO Box 20, 00014 University of Helsinki, Finland.
Trials. 2010 Oct 6;11:92. doi: 10.1186/1745-6215-11-92.
Besides cognitive decline, Alzheimer's disease (AD) leads to physical disability, need for help and permanent institutional care. The trials investigating effects of exercise rehabilitation on physical functioning of home-dwelling older dementia patients are still scarce. The aim of this study is to investigate the effectiveness of intensive exercise rehabilitation lasting for one year on mobility and physical functioning of home-dwelling patients with AD.
During years 2008-2010, patients with AD (n = 210) living with their spousal caregiver in community are recruited using central AD registers in Finland, and they are offered exercise rehabilitation lasting for one year. The patients are randomized into three arms: 1) tailored home-based exercise twice weekly 2) group-based exercise twice weekly in rehabilitation center 3) control group with usual care and information of exercise and nutrition. Main outcome measures will be Guralnik's mobility and balance tests and FIM-test to assess physical functioning. Secondary measures will be cognition, neuropsychiatric symptoms according to the Neuropsychiatric Inventory, caregivers' burden, depression and health-related quality of life (RAND-36). Data concerning admissions to institutional care and the use and costs of health and social services will be collected during a two year follow-up.
To our knowledge this is the first large scale trial exploring whether home-dwelling patients with AD will benefit from intense and long-lasting exercise rehabilitation in respect to their mobility and physical functioning. It will also provide data on cost-effectiveness of the intervention.
ACTRN12608000037303.
除了认知能力下降，阿尔茨海默病（AD）还会导致身体残疾、需要帮助和长期机构护理。目前，关于运动康复对居住在家中痴呆症老年患者身体功能影响的试验仍然很少。本研究旨在探讨为期一年的强化运动康复对居住在家中 AD 患者的移动能力和身体功能的有效性。
在 2008-2010 年期间，通过芬兰的中央 AD 登记处招募了居住在社区中、与配偶照顾者同住的 AD 患者（n=210），并为他们提供为期一年的运动康复。患者随机分为三组：1）每周两次的定制家庭运动；2）每周两次的康复中心小组运动；3）对照组接受常规护理以及运动和营养信息。主要结局指标为古拉尔尼克的移动和平衡测试以及 FIM 测试，以评估身体功能。次要指标包括认知、根据神经精神疾病问卷评估的神经精神症状、照顾者负担、抑郁和健康相关生活质量（RAND-36）。在两年的随访期间，将收集有关入住机构护理以及卫生和社会服务的使用和成本的数据。
据我们所知，这是第一个探索居住在家中的 AD 患者是否会从强化和长期运动康复中受益于移动能力和身体功能的大规模试验。它还将提供干预措施的成本效益数据。
ACTRN12608000037303。
