Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
Diabetes Res Clin Pract. 2010 Dec;90(3):365-71. doi: 10.1016/j.diabres.2010.09.010. Epub 2010 Oct 6.
Chronic airway inflammation in asthma or chronic obstructive pulmonary disease (COPD) may be involved in the pathogenesis of type 2 diabetes; however, prospective data have been limited.
A prospective cohort of 38,570 women who were aged ≥ 45 years, free of cardiovascular disease and cancer at baseline, and free of diabetes at baseline and in the first 12 months were analyzed. We classified all women into three groups according to the presence and absence of self-reported asthma or COPD (including emphysema, chronic bronchitis, and bronchiectasis).
During a median follow-up of 12.2 years, 2472 incident type 2 diabetes events were documented. Women who had ever reported asthma or COPD were associated with an increased diabetes risk; the multivariate RRs were 1.37 (95% CI, 1.20-1.57) for women who had asthma alone and 1.38 (95% CI, 1.14-1.67) for COPD without asthmatic symptoms. Furthermore, these associations were not significantly modified by age, smoking status, physical activity, BMI, alcohol intake, hormone replacement therapy, menopausal status or randomized treatment.
Asthma and COPD were individually and independently associated with an increased risk of type 2 diabetes in women, indicating that chronic airway inflammation may contribute to diabetes pathogenesis.
哮喘或慢性阻塞性肺疾病（COPD）的慢性气道炎症可能与 2 型糖尿病的发病机制有关；然而，前瞻性数据有限。
对 38570 名年龄≥45 岁、基线时无心血管疾病和癌症且基线和前 12 个月无糖尿病的女性进行了前瞻性队列研究。我们根据是否存在自述的哮喘或 COPD（包括肺气肿、慢性支气管炎和支气管扩张症）将所有女性分为三组。
中位随访 12.2 年后，记录了 2472 例新发 2 型糖尿病事件。曾报告患有哮喘或 COPD 的女性发生糖尿病的风险增加；多变量 RR 为 1.37（95%CI，1.20-1.57），仅患有哮喘的女性为 1.38（95%CI，1.14-1.67），无哮喘症状的 COPD 患者为 1.38（95%CI，1.14-1.67）。此外，这些关联不受年龄、吸烟状况、身体活动、BMI、饮酒量、激素替代疗法、绝经状态或随机治疗的显著改变。
哮喘和 COPD 单独且独立地与女性 2 型糖尿病风险增加相关，表明慢性气道炎症可能导致糖尿病发病机制。
