前列腺癌男性的膳食补充剂使用模式：瑞典癌症前列腺研究。

Dietary supplement use patterns in men with prostate cancer: the Cancer Prostate Sweden study.

机构信息

Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg.

Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg; Division of Clinical Cancer Epidemiology, Department of Oncology and Pathology, Karolinska Institutet, Stockholm.

出版信息

Ann Oncol. 2011 Apr;22(4):967-972. doi: 10.1093/annonc/mdq456. Epub 2010 Oct 6.

DOI:10.1093/annonc/mdq456

PMID:20926547

Abstract

BACKGROUND

In a European setting, we know little about the use of dietary supplements among men with prostate cancer (PCa) and to what extent lifestyle, disease or other factors influence such use.

PATIENTS AND METHODS

We evaluated supplement use in 1127 men with incident PCa and in 900 population controls in Sweden. Age-adjusted binary regression with an identity link was carried out to estimate prevalence differences and corresponding 95% confidence intervals (CIs). Modifying effects of lifestyle- and diet-related factors were explored by statistical assessment of additive interaction.

RESULTS

Among men with PCa, 542 individuals (48%) had used supplements, which was a 10% (95% CI: 5.9%-15%) higher prevalence than among population controls. Among individuals with high intake of fatty fish, vegetables, and phytoestrogens, but low intake of saturated fat, supplement use was 29% (95% CI: 18%-41%) more common in men with PCa than in population controls. We found no evidence of heterogeneity by categories of education, smoking history, body mass index, fiber, fruit, or phytoestrogen intake, treatment, or disease stage.

CONCLUSION

Supplement use is common in Swedish men with PCa, especially among those with a healthy dietary pattern.

摘要

背景

在欧洲环境下，我们对前列腺癌（PCa）男性中膳食补充剂的使用情况知之甚少，也不清楚生活方式、疾病或其他因素在何种程度上影响了这类使用。

患者与方法

我们在瑞典评估了 1127 名新发 PCa 男性患者和 900 名人群对照者中补充剂的使用情况。采用身份链接的年龄调整二项回归来估计患病率差异及其相应的 95%置信区间（CI）。通过对附加交互作用的统计评估，探索了生活方式和饮食相关因素的调节作用。

结果

在患有 PCa 的男性中，有 542 名（48%）人使用了补充剂，这一比例比人群对照者高 10%（95%CI：5.9%-15%）。在高脂肪鱼、蔬菜和植物雌激素摄入量高、而饱和脂肪摄入量低的人群中，与人群对照者相比，患有 PCa 的男性补充剂使用更为常见，比例高出 29%（95%CI：18%-41%）。我们未发现按教育程度、吸烟史、体重指数、纤维、水果或植物雌激素摄入量、治疗或疾病分期等类别存在异质性的证据。