Le Gal Kristell, Schmidt Edward E, Sayin Volkan I
Institute of Clinical Sciences, Department of Surgery, Sahlgrenska Center for Cancer Research, University of Gothenburg, 405 30 Gothenburg, Sweden.
Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
Antioxidants (Basel). 2021 Aug 28;10(9):1377. doi: 10.3390/antiox10091377.
Cellular redox homeostasis is an essential and dynamic process that ensures the balance between reducing and oxidizing reactions within cells and regulates a plethora of biological responses and events. The study of these biochemical reactions has proven difficult over time, but recent technical and methodological developments have contributed to the rapid growth of the redox field and to our understanding of its importance in biology. The aim of this short review is to give the reader an overall understanding of redox regulation in the areas of cellular signaling, development, and disease, as well as to introduce some recent discoveries in those fields.
细胞氧化还原稳态是一个至关重要的动态过程,它确保细胞内还原反应和氧化反应之间的平衡,并调节大量的生物反应和事件。随着时间的推移,对这些生化反应的研究已证明颇具难度,但近期技术和方法的发展推动了氧化还原领域的快速发展,也增进了我们对其在生物学中重要性的理解。这篇简短综述的目的是让读者全面了解细胞信号传导、发育和疾病领域中的氧化还原调节,同时介绍这些领域的一些最新发现。