Department of General Surgery, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China.
Dig Dis Sci. 2011 Apr;56(4):1090-8. doi: 10.1007/s10620-010-1416-x. Epub 2010 Oct 7.
CD151, c-Met, and integrin alpha3/alpha6 are all involved in the hepatocyte growth factor (HGF)/c-Met signal pathway, which plays an important role in the malignant progression of tumors.
The purpose of this study was to explore the expression and prognostic significance of these proteins in pancreatic ductal adenocarcinoma (PDAC).
We used immunohistochemical methods to investigate the expression patterns of CD151, c-Met, and integrin alpha3/alpha6proteins in 71 patients with PDAC and in ten samples of normal pancreatic tissue. We also assessed correlations between these proteins and clinicopathological parameters and survival of PDAC patients using various statistical methods.
CD151, c-Met, and integrin alpha3/alpha6 were all overexpressed in PDAC. CD151 and c-Met overexpressions were significantly associated with TNM stage (p=0.001 and p=0.038, respectively) and lymph node invasion (p=0.000, p=0.012, respectively). A significant positive linear correlation was found between CD151 and c-Met (r=0.583; p=0.000), integrin alpha3 (r=0.457; p=0.000), and integrin alpha6 (r=0.671; p=0.000). Overexpression of CD151, c-Met, integrin alpha3, or integrin alpha6 was related to poor survival of PDAC patients (p=0.000, p=0.000, p=0.005, and p=0.003, respectively), and CD151 and c-Met were independent factors in prognosis of PDAC.
CD151, c-Met, and integrin alpha3/alpha6 were all overexpressed in PDAC. CD151 and c-Met might be new molecular markers to predict the prognosis of PDAC patients.
CD151、c-Met 和整合素 α3/α6 均参与肝细胞生长因子（HGF）/c-Met 信号通路，该通路在肿瘤的恶性进展中发挥重要作用。
本研究旨在探讨 CD151、c-Met 和整合素 α3/α6 蛋白在胰腺导管腺癌（PDAC）中的表达及其预后意义。
我们使用免疫组织化学方法检测了 71 例 PDAC 患者和 10 例正常胰腺组织中 CD151、c-Met 和整合素 α3/α6 蛋白的表达模式。我们还使用各种统计方法评估了这些蛋白与 PDAC 患者临床病理参数和生存的相关性。
CD151、c-Met 和整合素 α3/α6 在 PDAC 中均过度表达。CD151 和 c-Met 的过度表达与 TNM 分期（p=0.001 和 p=0.038）和淋巴结侵犯（p=0.000、p=0.012）显著相关。CD151 与 c-Met（r=0.583；p=0.000）、整合素 α3（r=0.457；p=0.000）和整合素 α6（r=0.671；p=0.000）之间存在显著的正线性相关性。CD151、c-Met、整合素 α3 或整合素 α6 的过度表达与 PDAC 患者的不良生存相关（p=0.000、p=0.000、p=0.005 和 p=0.003），CD151 和 c-Met 是 PDAC 预后的独立因素。
CD151、c-Met 和整合素 α3/α6 在 PDAC 中均过度表达。CD151 和 c-Met 可能是预测 PDAC 患者预后的新分子标志物。
