Erasmus University Medical Center, Rotterdam, The Netherlands.
The ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus MC, Rotterdam, the Netherlands.
J Atten Disord. 2022 Feb;26(4):563-572. doi: 10.1177/10870547211012035. Epub 2021 May 12.
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that is associated with cognitive disabilities, including attention and motor learning problems. These disabilities have been extensively studied in children with NF1 but limited studies have been performed in adults.
Attention, motor learning and intellectual performance were studied with neuropsychological tasks in 32 adults with NF1 and 32 controls.
The NF1 and control group performed similarly on attention and motor learning tasks, although controls had shorter reaction times than adults with NF1 during the motor learning task ([60] = -2.20, = .03). Measures of attention or motor learning were not significantly associated with reduced intellectual performance in NF1.
In contrast to many studies in children with NF1, our findings did not provide evidence for presence of attention or motor learning problems in adults with NF1 in neuropsychological tasks. Our observations may be of clinical importance to determine treatment focus in adults with NF1.
神经纤维瘤病 1 型（NF1）是一种常染色体显性遗传疾病，与认知障碍有关，包括注意力和运动学习问题。这些残疾在 NF1 患儿中已得到广泛研究，但在成年患者中进行的研究有限。
对 32 名 NF1 成年患者和 32 名对照者进行了神经心理学任务，以研究注意力、运动学习和智力表现。
NF1 组和对照组在注意力和运动学习任务上的表现相似，尽管对照组在运动学习任务中的反应时间短于 NF1 成年患者 ([60] = -2.20, = .03)。注意力或运动学习的测量指标与 NF1 患者智力表现下降无显著相关性。
与许多 NF1 患儿的研究不同，我们的研究结果并未在神经心理学任务中为 NF1 成年患者存在注意力或运动学习问题提供证据。我们的观察结果可能对确定 NF1 成年患者的治疗重点具有重要的临床意义。
