Quintero-González Jesús Alberto
Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
Invest Clin. 2010 Jun;51(2):269-87.
Warfarin is the most utilized oral anticoagulant for the long term prophylaxes of thrombosis. Its use has been increased as new clinical conditions, capable of leading to thrombosis, have been detected. Due to the special characteristics of warfarin, such as the variability of doses for each individual, the narrow margin between adequate and inadequate doses, interaction with multiple pharmaceutical products, interference of its action by vitamin K present in the diet and the possibility of hemorrhagic complications or thrombotic recurrence, this drug requires a very careful dosage and strict laboratory and clinical monitoring. Despite being in the market for more than de fifty years and its many disadvantages, warfarin has not been substituted for the new oral anticoagulants. In 1999, warfarin was positioned eleventh on the list of the most used medicines in the world.
华法林是用于长期预防血栓形成的最常用口服抗凝剂。随着能够导致血栓形成的新临床病症被发现，其使用量有所增加。由于华法林具有特殊特性，比如个体剂量的变异性、有效剂量与无效剂量之间的范围狭窄、与多种药品相互作用、饮食中维生素K对其作用的干扰以及出血并发症或血栓复发的可能性，这种药物需要非常谨慎地给药以及严格的实验室和临床监测。尽管华法林已上市五十多年且存在诸多缺点，但它尚未被新型口服抗凝剂所取代。1999年，华法林在世界最常用药品名单中位列第十一。
