Musani Muhammad Ayub, Jawed Itrat, Marfani Saleem, Khambaty Yousuf, Jalisi M, Khan Shahbaz Ali
Department of ENT, Karachi Medical and Dental College, Abbasi Shaeed Hospital, Karachi.
J Ayub Med Coll Abbottabad. 2009 Jul-Sep;21(3):87-91.
Oral cancer varies globally and regionally, and is closely linked with geographical, social, economical, biological, ethnic, dietary and environmental factors. In western countries it accounts for about 2-5% while in the south-east Asia for about 40% of all cancers. In Pakistan it is second commonest tumour after bronchogenic carcinoma in males and breast carcinoma in females. The objectives of this study were to find out the pattern of carcinoma cheek in our region, its etiological associations, management and prognosis. This study was conducted in the Otolaryngology and Head and Neck Surgery Department of Civil Hospital, Karachi from April 1995 to December 1998. It was prospective study.
Forty-five cases of primary carcinoma cheek were diagnosed and investigations including OPG and CT scan were carried out along with other required investigations to evaluate the extension of tumour, bony erosion and metastasis. TNM staging was done. All patients were treated surgically, sent for post-operative radiotherapy or chemoradiation and followed up for 3 years.
Among 45 cases of oral cancer, 28 were females and 17 were males. Common presenting symptom was growth or ulcer. It was more common in 41-50 years of age. Squamous cell carcinoma (SCC) was found in 95.5% of the cases. Most of the patients 31 (68%) were in T4 stage. Surgical excision was done in all cases with reconstructuion in 23 cases and neck dissection in 39 cases. In the follow up for 3 years, 30 patient remained disease free.
Carcinoma cheek is a common entity in our region and now it is seen in relatively younger patients. Oral cancer is a self preventable disease. What is required is to develop awareness of oral hygiene and discourage the habit of social carcinogens use. Early diagnosis and treatment offers better chance of cure whereas advance disease has a poor prognosis.
口腔癌在全球和区域范围内存在差异,并且与地理、社会、经济、生物学、种族、饮食和环境因素密切相关。在西方国家,它约占所有癌症的2%-5%,而在东南亚约占40%。在巴基斯坦,它是男性继支气管癌、女性继乳腺癌之后的第二常见肿瘤。本研究的目的是找出我们地区颊癌的发病模式、病因关联、治疗方法及预后情况。本研究于1995年4月至1998年12月在卡拉奇市民医院耳鼻喉科及头颈外科进行。这是一项前瞻性研究。
诊断出45例原发性颊癌病例,并进行了包括口腔全景片(OPG)和CT扫描在内的检查以及其他所需检查,以评估肿瘤的扩展、骨质侵蚀和转移情况。进行了TNM分期。所有患者均接受手术治疗,术后接受放疗或放化疗,并随访3年。
在45例口腔癌病例中,女性28例,男性17例。常见的症状是肿物或溃疡。在41-50岁年龄段更为常见。95.5%的病例为鳞状细胞癌(SCC)。大多数患者31例(68%)处于T4期。所有病例均进行了手术切除,23例进行了重建,39例进行了颈部清扫。在3年的随访中,30例患者无疾病复发。
颊癌在我们地区是一种常见疾病,现在在相对年轻的患者中也可见到。口腔癌是一种可自我预防的疾病。需要提高口腔卫生意识,摒弃使用社会致癌物的习惯。早期诊断和治疗提供了更好的治愈机会,而晚期疾病预后较差。