Medical Service, Louis Stokes Cleveland VA Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA.
Infect Control Hosp Epidemiol. 2010 Nov;31 Suppl 1:S7-10. doi: 10.1086/655995.
The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are responsible for a substantial percentage of nosocomial infections in the modern hospital and represent the vast majority of isolates whose resistance to antimicrobial agents presents serious therapeutic dilemmas for physicians. Over the years, improved molecular biology techniques have led to detailed information about individual resistance mechanisms in all these pathogens. However, there remains a lack of compelling data on the interplay between resistance mechanisms and between the bacteria themselves. In addition, data on the impact of clinical interventions to decrease the prevalence of resistance are also lacking. The difficulty in identifying novel antimicrobial agents with reliable activity against these pathogens argues for an augmentation of research in the basic and population science of resistance, as well as careful studies to identify optimal strategies for infection control and antimicrobial use.
ESKAPE 病原体（屎肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌属）是现代医院中导致大量医院获得性感染的罪魁祸首，也是绝大多数对抗菌药物耐药的分离株，这给临床医生带来了严重的治疗困境。多年来，分子生物学技术的进步为所有这些病原体的个体耐药机制提供了详细信息。然而，关于耐药机制之间以及细菌之间相互作用的有力数据仍然缺乏。此外，关于减少耐药流行的临床干预措施的影响的数据也缺乏。由于难以确定对这些病原体具有可靠活性的新型抗菌药物，因此需要加强耐药的基础和人群科学研究，并进行精心研究以确定感染控制和抗菌药物使用的最佳策略。
