ESKAPE 病原体的临床相关性。

Clinical relevance of the ESKAPE pathogens.

机构信息

School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK.

出版信息

Expert Rev Anti Infect Ther. 2013 Mar;11(3):297-308. doi: 10.1586/eri.13.12.

DOI:10.1586/eri.13.12

Abstract

In recent years, the Infectious Diseases Society of America has highlighted a faction of antibiotic-resistant bacteria (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) - acronymically dubbed 'the ESKAPE pathogens' - capable of 'escaping' the biocidal action of antibiotics and mutually representing new paradigms in pathogenesis, transmission and resistance. This review aims to consolidate clinically relevant background information on the ESKAPE pathogens and provide a contemporary summary of bacterial resistance, alongside pertinent microbiological considerations necessary to face the mounting threat of antimicrobial resistance.

摘要

近年来，美国传染病学会强调了一组具有抗药性的细菌（粪肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和阴沟肠杆菌）——首字母缩略词为“ESKAPE 病原体”——能够“逃避”抗生素的杀菌作用，并在发病机制、传播和耐药性方面代表了新的范例。本综述旨在整合关于 ESKAPE 病原体的临床相关背景信息，并提供有关细菌耐药性的当代总结，以及应对抗微生物药物耐药性日益严重威胁所需的相关微生物学考虑因素。