Department of Pediatrics, Oslo University Hospital Ullevål, University of Oslo, Norway.
Acta Obstet Gynecol Scand. 2010 Nov;89(11):1403-11. doi: 10.3109/00016349.2010.518594. Epub 2010 Oct 8.
To estimate the risk of congenital anomalies in offspring of women with type 1 diabetes in Norway during recent years.
Nationwide population-based study using the Medical Birth Registry of Norway and the Norwegian type 1 Diabetes Registry.
All birth clinics in Norway.
All births in Norway during 1999-2004 (N = 350,961), of which 1,583 were births by a mother registered with pregestational type 1 diabetes.
Congenital anomalies, excluding minor anomalies according to the EUROCAT system.
Anomalies were registered in 5.7% of offspring of women with type 1 diabetes, and in 2.9% among the background population (odds ratio 2.1, 95% CI: 1.7-2.6). Cardiovascular anomalies were registered in 3.2% in the diabetes group and 0.94% in the background population (odds ratio 3.5, 95% CI: 2.7-4.7). Results were similar when restricted to women identified with type 1 diabetes through the Diabetes Registry.
Women in Norway with type 1 diabetes experience a significantly higher risk of congenital anomalies in their babies compared with the background population.
评估近年来挪威 1 型糖尿病女性后代先天畸形的风险。
利用挪威医学出生登记处和 1 型糖尿病登记处进行全国性基于人群的研究。
挪威所有的分娩诊所。
1999-2004 年期间挪威所有的分娩（N=350961），其中 1583 例是患有妊娠前 1 型糖尿病的母亲所分娩。
先天畸形，不包括 EUROCAT 系统中的轻微畸形。
1 型糖尿病女性后代的畸形发生率为 5.7%，而背景人群为 2.9%（比值比 2.1，95%可信区间：1.7-2.6）。糖尿病组心血管畸形的发生率为 3.2%，背景人群为 0.94%（比值比 3.5，95%可信区间：2.7-4.7）。通过糖尿病登记处确定的 1 型糖尿病女性也有类似的结果。
与背景人群相比，挪威的 1 型糖尿病女性其后代发生先天畸形的风险显著增加。
