Palma-Padilla Virginia, Juárez-Ocaña Servando, González-Miranda Guadalupe, Siordia-Reyes Alicia Georgina, Mejía-Aranguré Juan Manuel, Carreón-Cruz Rogelio, Fajardo-Gutiérrez Arturo
Registro de Cáncer en Niños, Unidad de Investigación Médica en Epidemiología Clínica, Instituto Mexicano del Seguro Social, Distrito Federal, Mexico.
Rev Med Inst Mex Seguro Soc. 2010 Mar-Apr;48(2):151-8.
Neuroblastoma (NB) is the principal tumor of the sympathetic nervous system in children.
to describe the epidemiological and clinical characteristics of Mexican children with NB.
A population-based, prolective study, with data obtained from the Childhood Cancer Registry of the Instituto Mexicano del Seguro Social. The frequencies and incidence of the variables of the study were obtained by age and sex. The trend was calculated with the annual percentage of change.
Of a total of 2758 children with cancer, 72 (2.6%) were identified in the Group IV, according to the International Classification of Childhood Cancer. The average incidence for NB was 3.8, the highest incidence was found in Guerrero. NB was highest in the group under one year of age (18.5). The male/female ratio was 1.1 and there was no trend toward an increase. Stages III and IV were presented in 88% of the cases. There was no association between the stages, the age at the TD, or the histological pattern.
It is possible that the low incidence of NB in Mexican children is due to the difficulty in early diagnosis due the majority of the cases was diagnosed in the advanced stages.
神经母细胞瘤（NB）是儿童交感神经系统的主要肿瘤。
描述墨西哥患NB儿童的流行病学和临床特征。
一项基于人群的前瞻性研究，数据来自墨西哥社会保障局儿童癌症登记处。通过年龄和性别得出研究变量的频率和发病率。用年度变化百分比计算趋势。
在总共2758名患癌儿童中，根据国际儿童癌症分类，IV组中有72名（2.6%）被确诊。NB的平均发病率为3.8，最高发病率出现在格雷罗州。NB在1岁以下组中发病率最高（18.5）。男女比例为1.1，且无上升趋势。88%的病例为III期和IV期。分期、确诊时年龄或组织学模式之间无关联。
墨西哥儿童NB发病率低可能是由于大多数病例在晚期才被诊断出来，导致早期诊断困难。
