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轻度认知障碍患者的生成效应。

The generation effect in patients with mild cognitive impairment.

机构信息

Department of Psychology, University of Oviedo, Spain.

出版信息

Am J Alzheimers Dis Other Demen. 2010 Nov;25(7):576-84. doi: 10.1177/1533317510382284.

DOI:10.1177/1533317510382284
PMID:20930187
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10845521/
Abstract

The generation effect (GE) has been proven as an effective technique to improve learning and memory in healthy and clinical populations. However, it has not been found with meaningless materials such as pseudowords. Several hypotheses postulate the participation of semantic memory in the information-generating process. There is indeed a clear decrease in the effect in patients with serious semantic memory disorders, such as Alzheimer's disease (AD) but, if this is correct, other patients whose memory disorders are not so serious, such as mild cognitive impairment (MCI), should show GE to some extent. To test this hypothesis, we examined 54 participants (18 healthy adults, 18 patients with AD, and 18 with MCI) in a task involving reading and completion of phrases. Results show a decreased (although obvious) GE in patients with MCI. Likewise, results indicate that greater semantic damage will lead to poorer performance with less familiar stimuli or low-frequency words.

摘要

生成效应 (GE) 已被证明是一种有效提高健康人群和临床人群学习和记忆的技术。然而,它在无意义的材料(如伪词)中并未发现。一些假说假设语义记忆参与了信息生成过程。在阿尔茨海默病 (AD) 等严重语义记忆障碍的患者中,确实明显降低了该效应,但如果这是正确的,那么其他记忆障碍不太严重的患者,如轻度认知障碍 (MCI),应该在某种程度上表现出 GE。为了验证这一假设,我们在一项涉及阅读和完成短语的任务中对 54 名参与者(18 名健康成年人、18 名 AD 患者和 18 名 MCI 患者)进行了测试。结果表明,MCI 患者的 GE 明显降低(尽管仍明显)。同样,结果表明,更大的语义损伤将导致对不熟悉的刺激或低频词的表现更差。

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本文引用的文献

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An investigation of the differential effect of self-generation to improve learning and memory in multiple sclerosis and traumatic brain injury.关于自我生成对改善多发性硬化症和创伤性脑损伤患者学习与记忆的差异效应的研究。
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Temporal lobe lesions and semantic impairment: a comparison of herpes simplex virus encephalitis and semantic dementia.颞叶病变与语义障碍:单纯疱疹病毒性脑炎与语义性痴呆的比较
Brain. 2007 Apr;130(Pt 4):1138-47. doi: 10.1093/brain/awl344. Epub 2007 Jan 24.
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The representation of object concepts in the brain.大脑中客体概念的表征。
Annu Rev Psychol. 2007;58:25-45. doi: 10.1146/annurev.psych.57.102904.190143.
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Self-generated learning in people with multiple sclerosis.多发性硬化症患者的自主学习
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Test-enhanced learning: taking memory tests improves long-term retention.测试强化学习:进行记忆测试可提高长期记忆保持能力。
Psychol Sci. 2006 Mar;17(3):249-55. doi: 10.1111/j.1467-9280.2006.01693.x.
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Design your own memory strategies! Self-generated strategy training versus mnemonic training in old age: an 8-month follow-up.设计你自己的记忆策略!老年自我生成策略训练与记忆术训练:8个月随访
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The neural mechanisms of speech comprehension: fMRI studies of semantic ambiguity.言语理解的神经机制:语义歧义的功能磁共振成像研究
Cereb Cortex. 2005 Aug;15(8):1261-9. doi: 10.1093/cercor/bhi009. Epub 2005 Jan 5.
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Contributions of sensory input, auditory search and verbal comprehension to cortical activity during speech processing.言语处理过程中感觉输入、听觉搜索和言语理解对皮质活动的贡献。
Cereb Cortex. 2004 Mar;14(3):247-55. doi: 10.1093/cercor/bhg124.