阿尔茨海默病问卷：一种新的基于知情者的痴呆评估方法的概念验证研究。
The Alzheimer's questionnaire: a proof of concept study for a new informant-based dementia assessment.
机构信息
The Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA.
出版信息
J Alzheimers Dis. 2010;22(3):1015-21. doi: 10.3233/JAD-2010-101185.
Abstract
The aim of this pilot study is to determine the feasibility and clinical utility of a brief, informant-based screening questionnaire for Alzheimer's disease (AD) that can be administered in a primary care setting. The Alzheimer's Questionnaire (AQ) was administered to the informants of 188 patients in 3 dementia clinics (50 cognitively normal, 69 mild cognitive impairment (MCI), 69 AD). Total score for the AQ is based upon the sum of clinical symptom items in which the informant responds as being present. Clinical symptoms which are known to be highly predictive of the clinical AD diagnosis are given greater weight in the total AQ score. The mean time of administration of the AQ was 2.6 ± 0.6 minutes. Sensitivity and specificity were found to be high for detecting both AD (98.55, 96.00) and MCI (86.96, 94.00) with ROC curves yielding AUC values of 0.99 and 0.95, respectively. This pilot study indicates that the AQ is a brief, sensitive measure for detecting both MCI and AD and could be easily implemented in a primary care setting.
摘要
本初步研究旨在确定一种基于简要的、可由信息提供者提供的阿尔茨海默病（AD）筛查问卷的可行性和临床实用性，这种问卷可在初级保健环境中进行管理。在 3 家痴呆症诊所（50 名认知正常者、69 名轻度认知障碍者（MCI）和 69 名 AD 患者）的信息提供者中，对阿尔茨海默病问卷（AQ）进行了评估。AQ 的总分为信息提供者报告存在的临床症状项目的总和。已知对 AD 临床诊断具有高度预测性的临床症状在总 AQ 评分中赋予了更大的权重。AQ 的平均管理时间为 2.6±0.6 分钟。检测 AD（98.55、96.00）和 MCI（86.96、94.00）的灵敏度和特异性均较高，ROC 曲线产生的 AUC 值分别为 0.99 和 0.95。这项初步研究表明，AQ 是一种用于检测 MCI 和 AD 的简便、敏感的方法，可在初级保健环境中轻松实施。
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本文引用的文献
1
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Alzheimers Dement. 2006 Apr;2(2):76-85. doi: 10.1016/j.jalz.2006.02.005.
2
Validity and reliability of the AD8 informant interview in dementia.AD8知情者访谈在痴呆症中的效度和信度
Neurology. 2006 Dec 12;67(11):1942-8. doi: 10.1212/01.wnl.0000247042.15547.eb.
3
Improving identification of cognitive impairment in primary care.改善基层医疗中认知障碍的识别。
Int J Geriatr Psychiatry. 2006 Apr;21(4):349-55. doi: 10.1002/gps.1470.
4
The AD8: a brief informant interview to detect dementia.AD8：一种用于检测痴呆症的简短 informant 访谈。 （注：这里 informant 直译为“提供信息者”，在医学语境中可理解为访谈对象等，具体含义需结合上下文确定）
Neurology. 2005 Aug 23;65(4):559-64. doi: 10.1212/01.wnl.0000172958.95282.2a.
5
Implementing a screening and diagnosis program for dementia in primary care.在初级保健中实施痴呆症筛查与诊断项目。
J Gen Intern Med. 2005 Jul;20(7):572-7. doi: 10.1111/j.1525-1497.2005.0126.x.
6
The Informant Questionnaire on cognitive decline in the elderly (IQCODE): a review.老年人认知功能减退情况知情者问卷（IQCODE）：综述
Int Psychogeriatr. 2004 Sep;16(3):275-93. doi: 10.1017/s1041610204000390.
7
Screening for dementia in primary care: a summary of the evidence for the U.S. Preventive Services Task Force.基层医疗中痴呆症的筛查：美国预防服务工作组的证据总结
Ann Intern Med. 2003 Jun 3;138(11):927-37. doi: 10.7326/0003-4819-138-11-200306030-00015.
8
The mini-cog: a cognitive 'vital signs' measure for dementia screening in multi-lingual elderly.简易认知筛查量表：一种用于多语言老年人痴呆筛查的认知“生命体征”测量方法。
Int J Geriatr Psychiatry. 2000 Nov;15(11):1021-7. doi: 10.1002/1099-1166(200011)15:11<1021::aid-gps234>3.0.co;2-6.
9
The detection of dementia in the primary care setting.基层医疗环境中痴呆症的检测。
Arch Intern Med. 2000 Oct 23;160(19):2964-8. doi: 10.1001/archinte.160.19.2964.
10
Clock-drawing: is it the ideal cognitive screening test?画钟试验：它是理想的认知筛查测试吗？
Int J Geriatr Psychiatry. 2000 Jun;15(6):548-61. doi: 10.1002/1099-1166(200006)15:6<548::aid-gps242>3.0.co;2-u.
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