The Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA.
J Alzheimers Dis. 2010;22(3):1015-21. doi: 10.3233/JAD-2010-101185.
The aim of this pilot study is to determine the feasibility and clinical utility of a brief, informant-based screening questionnaire for Alzheimer's disease (AD) that can be administered in a primary care setting. The Alzheimer's Questionnaire (AQ) was administered to the informants of 188 patients in 3 dementia clinics (50 cognitively normal, 69 mild cognitive impairment (MCI), 69 AD). Total score for the AQ is based upon the sum of clinical symptom items in which the informant responds as being present. Clinical symptoms which are known to be highly predictive of the clinical AD diagnosis are given greater weight in the total AQ score. The mean time of administration of the AQ was 2.6 ± 0.6 minutes. Sensitivity and specificity were found to be high for detecting both AD (98.55, 96.00) and MCI (86.96, 94.00) with ROC curves yielding AUC values of 0.99 and 0.95, respectively. This pilot study indicates that the AQ is a brief, sensitive measure for detecting both MCI and AD and could be easily implemented in a primary care setting.
本初步研究旨在确定一种基于简要的、可由信息提供者提供的阿尔茨海默病（AD）筛查问卷的可行性和临床实用性，这种问卷可在初级保健环境中进行管理。在 3 家痴呆症诊所（50 名认知正常者、69 名轻度认知障碍者（MCI）和 69 名 AD 患者）的信息提供者中，对阿尔茨海默病问卷（AQ）进行了评估。AQ 的总分为信息提供者报告存在的临床症状项目的总和。已知对 AD 临床诊断具有高度预测性的临床症状在总 AQ 评分中赋予了更大的权重。AQ 的平均管理时间为 2.6±0.6 分钟。检测 AD（98.55、96.00）和 MCI（86.96、94.00）的灵敏度和特异性均较高，ROC 曲线产生的 AUC 值分别为 0.99 和 0.95。这项初步研究表明，AQ 是一种用于检测 MCI 和 AD 的简便、敏感的方法，可在初级保健环境中轻松实施。
