Budolfson Katherine, Malek-Ahmadi Michael, Belden Christine M, Powell Jessica, Davis Kathryn, Jacobson Sandra, Sabbagh Marwan N
The Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ, USA.
University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.
J Alzheimers Dis. 2015;46(2):389-97. doi: 10.3233/JAD-142388.
Informant-based assessments of cognition and function are commonly used to differentiate individuals with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) from those who are cognitively normal. However, determining the extent to which informant-based measures correlate to objective neuropsychological tests is important given the widespread use of neuropsychological tests in making clinical diagnoses of aMCI and AD. The aim of the current study is to determine how well the Alzheimer's Questionnaire (AQ) correlates with objective neuropsychological tests. The study utilized data from 300 individuals participating in a brain and body donation program. Individuals diagnosed with aMCI (n = 83) and AD (n = 67) were matched on age, gender, and education to a control individual (n = 150). The average age for the entire sample was 83.52±6.51 years with an average education level of 14.57±2.55 years. Results showed that the AQ correlated strongly with the Mini-Mental State Exam (r =-0.71, p < 0.001) and the Mattis Dementia Rating Scale-2 (r =-0.72, p < 0.001), and moderate correlations were noted for the AQ with memory function (Rey Auditory Verbal Learning Test Delayed Recall, r =-0.61, p < 0.001) and executive function (Trails B, r = 0.53, p < 0.001). The findings of this study suggest that the AQ correlates well with several neuropsychological tests and lend further support to the validity of the AQ as a screening instrument for cognitive impairment.
基于 informant 的认知和功能评估通常用于区分患有遗忘型轻度认知障碍（aMCI）和阿尔茨海默病（AD）的个体与认知正常的个体。然而，鉴于神经心理学测试在 aMCI 和 AD 的临床诊断中广泛使用，确定基于 informant 的测量与客观神经心理学测试的相关程度很重要。本研究的目的是确定阿尔茨海默病问卷（AQ）与客观神经心理学测试的相关性有多好。该研究利用了参与脑与身体捐赠项目的 300 名个体的数据。将被诊断为 aMCI（n = 83）和 AD（n = 67）的个体在年龄、性别和教育程度上与对照个体（n = 150）进行匹配。整个样本的平均年龄为 83.52±6.51 岁，平均教育水平为 14.57±2.55 年。结果表明，AQ 与简易精神状态检查表（r = -0.71，p < 0.001）和马蒂斯痴呆评定量表 -2（r = -0.72，p < 0.001）高度相关，并且 AQ 与记忆功能（雷伊听觉词语学习测验延迟回忆，r = -0.61，p < 0.001）和执行功能（连线测验 B，r = 0.53，p < 0.001）存在中度相关。本研究结果表明，AQ 与多项神经心理学测试相关性良好，并进一步支持了 AQ 作为认知障碍筛查工具的有效性。
