Department of Biology, Institute of Cell Biology, ETH Zurich, Hönggerberg Campus, Switzerland.
EMBO Rep. 2010 Nov;11(11):834-40. doi: 10.1038/embor.2010.160. Epub 2010 Oct 8.
Mitogen-activated protein kinase (MAPK) signalling occurs in response to almost any change in the extracellular or intracellular milieu that affects the metabolism of the cell, organ or the entire organism. MAPK-dependent signal transduction is required for physiological metabolic adaptation, but inappropriate MAPK signalling contributes to the development of several interdependent pathological traits, collectively known as metabolic syndrome. Metabolic syndrome leads to life-threatening clinical consequences, such as type 2 diabetes. This Review provides an overview of the MAPK-signalling mechanisms that underly basic cellular metabolism, discussing their link to disease.
丝裂原活化蛋白激酶（MAPK）信号转导发生于细胞外或细胞内环境发生的几乎任何变化之后，这些变化会影响细胞、器官或整个生物体的新陈代谢。MAPK 依赖性信号转导是生理代谢适应所必需的，但不适当的 MAPK 信号转导有助于几种相互依赖的病理特征的发展，这些特征统称为代谢综合征。代谢综合征会导致危及生命的临床后果，如 2 型糖尿病。本文综述了基础细胞代谢所依赖的 MAPK 信号转导机制，并讨论了它们与疾病的联系。
