Ishikawa M, Sasaki K, Yakayanagi Y, Sasaki K
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Res Commun Chem Pathol Pharmacol. 1990 Dec;70(3):367-70.
In male rats bearing carrageenan-induced paw edema twenty-four hours after treatment with carrageenan the duration of hexobarbital hypnosis was prolonged and the rate of hepatic hexobarbital metabolism was inhibited. By contrast, treatment with carrageenan potentiates zoxazolamine paralysis time and inhibits zoxazolamine metabolism in both male and female rats. Thus, sex-related differences in the rats bearing carrageenan-induced paw edema and inhibition of drug metabolism are apparently substrate dependent.
在角叉菜胶诱导足爪水肿的雄性大鼠中，给予角叉菜胶24小时后，己巴比妥催眠持续时间延长，肝脏己巴比妥代谢速率受到抑制。相比之下，角叉菜胶处理可增强唑沙宗在雄性和雌性大鼠中的麻痹时间，并抑制唑沙宗代谢。因此，角叉菜胶诱导足爪水肿及药物代谢抑制的大鼠中与性别相关的差异显然依赖于底物。
