Ishikawa M, Sasaki K, Ozaki M, Takayanagi Y, Sasaki K
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Res Commun Chem Pathol Pharmacol. 1989 Aug;65(2):261-4.
Twenty-four hours after treatment with carrageenan the duration of hexobarbital-induced hypnosis was prolonged in males but not females in Wistar rats bearing carrageenan-induced paw edema. Similar treatment with carrageenan led to significant inhibition of the metabolism of hexobarbital by hepatic enzymes obtained from male but not female animals. These data suggest that there is a sex-related difference in the ability of carrageenan to alter drug actions in rats.
用角叉菜胶处理24小时后，在患有角叉菜胶诱导的爪部水肿的Wistar大鼠中，雄性大鼠戊巴比妥诱导的催眠持续时间延长，而雌性大鼠则不然。用角叉菜胶进行类似处理可显著抑制从雄性而非雌性动物获得的肝酶对戊巴比妥的代谢。这些数据表明，角叉菜胶改变大鼠药物作用的能力存在性别相关差异。
