镉对雄性和雌性大鼠唑沙胺代谢的抑制作用。
Cadmium-induced inhibition of zoxazolamine metabolism in male and female rats.
作者信息
Pence D H, Schnell R C
出版信息
Res Commun Chem Pathol Pharmacol. 1980 Feb;27(2):413-6.
PMID:7367758
Abstract
Pretreatment of rats with cadmium potentiates the duration of hexobarbital hypnosis and inhibits the rate of hepatic hexobarbital metabolism in male and female rats. In contrast, treatment with cadmium pe and female rats. Thus, sex-related differences in cadmium inhibition of hepatic drug metabolism is apparently substrate dependent.
摘要
用镉对大鼠进行预处理可延长雄性和雌性大鼠中己巴比妥催眠的持续时间，并抑制肝脏中己巴比妥的代谢速率。相比之下，用镉处理对雄性和雌性大鼠肝脏药物代谢的抑制作用存在性别相关差异。因此，镉对肝脏药物代谢的抑制作用中与性别相关的差异显然取决于底物。
Zotero 插件