Sex-related differences in drug-metabolizing enzyme activity of rats in carrageenan-induced inflammation.

Sex related differences in drugs metabolizing enzymes was studied using Wistar-rats bearing carrageenan-induced edema. One day after treatment with carrageenan, aminopyrine N-demethylase activity was inhibited in males but not in females. Carrageenan treatment did not alter the activity of aniline hydroxylase in either sex of the rats. These data show that there is a sex-related difference in the ability of carrageenan to alter the hepatic drug metabolism, which is substrate specific, in the rat.