Kan Juntao, Wu Feng, Wang Feijie, Zheng Jianheng, Cheng Junrui, Li Yuan, Yang Yuexin, Du Jun
Nutrilite Health Institute, Shanghai, China.
Sequanta Technologies Co., Ltd., Shanghai, China.
Front Nutr. 2022 Aug 16;9:960309. doi: 10.3389/fnut.2022.960309. eCollection 2022.
Phytonutrients are natural bioactive components present in the daily diet that can exert a positive impact on human health. Studies have shown that phytonutrients may act as antioxidants and improve metabolism after being ingested, which help to regulate physiological processes and prevent metabolic disorders and diseases. However, their efficacy is limited by their low bioavailability. The gut microbiota is symbiotic with humans and its abundance and profile are related to most diseases. Interestingly, studies have shown that the gut microbiota is associated with the metabolism of phytonutrients by converting them into small molecules that can be absorbed by the body, thereby enhancing their bioavailability. Furthermore, phytonutrients can modulate the composition of the gut microbiota, and therefore improve the host's health. Here, we focus on uncovering the mechanisms by which phytonutrients and gut microbiota play roles in health, and the interrelationships between phytonutrients and gut microbiota were summarized. We also reviewed the studies that reported the efficacy of phytonutrients in human health and the future directions.
植物营养素是日常饮食中存在的天然生物活性成分，对人体健康可产生积极影响。研究表明，植物营养素摄入后可作为抗氧化剂并改善新陈代谢，有助于调节生理过程，预防代谢紊乱和疾病。然而，它们的功效受到其低生物利用度的限制。肠道微生物群与人类共生，其丰度和组成与大多数疾病相关。有趣的是，研究表明，肠道微生物群通过将植物营养素转化为可被人体吸收的小分子来参与植物营养素的代谢，从而提高其生物利用度。此外，植物营养素可以调节肠道微生物群的组成，进而改善宿主健康。在此，我们着重揭示植物营养素和肠道微生物群在健康中发挥作用的机制，并总结植物营养素与肠道微生物群之间的相互关系。我们还回顾了报道植物营养素对人类健康功效的研究以及未来的研究方向。
