School of Pharmaceutical Sciences, Shoolini University, Bajhol, Solan H.P., India.
Curr Drug Targets. 2013 Sep;14(10):1210-8. doi: 10.2174/13894501113149990168.
Curcumin, a natural polyphenolic compound present in turmeric, exhibited multiple pharmacological activities. Extensive studies in last two decade suggested that curcumin possesses anti-inflammatory, anticancer, antiviral, anti-amyloid, antiarthritic and antioxidant properties. The mechanism for these effects involves modulation of several signaling transduction pathways. Various clinical studies have suggested that curcumin might be a potential candidate for the prevention and/or treatment of a variety of colonic diseases such as ulcerative colitis, Crohn's disease and colonic cancer. However, several evidences suggested the role of curcumin in multiple diseases, but the major challenge is to obtain optimum therapeutic levels of curcumin due to its low solubility and poor bioavailability. Improved absorption and cellular uptake of curcumin can be achieved through alteration in formulation properties and novel approaches in delivery systems. This review presents an overview of the background of curcumin, pharmacology, pharmacokinetics, clinical evidence in chemoprevention of bowel diseases and recent approaches to deliver curcumin for improved cellular uptake and bioavailability.
姜黄素是姜黄中的一种天然多酚化合物，具有多种药理作用。过去二十年的广泛研究表明，姜黄素具有抗炎、抗癌、抗病毒、抗淀粉样蛋白、抗关节炎和抗氧化作用。这些作用的机制涉及对几种信号转导途径的调节。多项临床研究表明，姜黄素可能是预防和/或治疗溃疡性结肠炎、克罗恩病和结肠癌等多种结肠疾病的潜在候选药物。然而，有几项证据表明姜黄素在多种疾病中的作用，但主要的挑战是由于其低溶解度和生物利用度差而获得最佳的姜黄素治疗水平。通过改变制剂特性和新的给药系统方法，可以提高姜黄素的吸收和细胞摄取。本文综述了姜黄素的背景、药理学、药代动力学、在预防肠道疾病方面的临床证据以及提高细胞摄取和生物利用度的最新给药方法。
