Department of Biomedical and NeuroMotor Sciences, University of Bologna, Italy.
Laboratoire de Psychologie Médicale, Université Libre de Bruxelles, Centre Européen de Psychologie Médicale-PsyPluriel, Brussels, Belgium.
J Affect Disord. 2019 Jun 1;252:464-474. doi: 10.1016/j.jad.2019.04.031. Epub 2019 Apr 9.
personality features have been repeatedly associated with depression treatment outcome in Major Depressive Disorder (MDD), however conclusive results are still lacking. Moreover, as for Bipolar Disorder (BD), results are only few and preliminary.
the aim of the present study was to perform an exploratory investigation of the influence of personality traits as assessed by the Temperament and Character Inventory (TCI), on principal depression treatment outcomes (non remission, non response and resistance).
743 mood disorders patients (455 MDD (61.24%) and 288 BD (38.76%)) were recruited in the context of 6 European studies. Generalized logit models were performed to test the effects of TCI dimensions on treatment outcomes, considering possible confounders such as age, gender and education. Positive results were controlled for comorbidities (anxiety and substance use disorders) as well.
MDD Non-Remitters showed high Harm Avoidance (HA) and Self Transcendence (ST) (p = 0.0004, d = 0.40; p = 0.007, d = 0.36 respectively) and low Persistence (P) and Self Directedness (SD) (p = 0.05; d = 0.18; p = 0.002, d = 0.40, respectively); MDD Non-Responders showed a slightly different profile with high HA and low Reward Dependence (RD) and SD; finally, MDD Resistants showed low RD, P and Cooperativeness (C). In BD patients, only higher HA in non response was observed.
the retrospective cross-sectional design, the TCI assessment regardless of the mood state and the small number of bipolar patients represent the main limitations.
specific TCI personality traits are associated with depression treatment outcome in MDD patients. The inclusion of such personality traits, together with other socio-demographic and clinical predictors, could ameliorate the accuracy of the prediction models available to date.
人格特征与重性抑郁障碍（MDD）的抑郁治疗结果反复相关，但结论仍缺乏一致性。此外，对于双相障碍（BD），结果也为数不多且初步。
本研究旨在通过使用气质与性格量表（TCI）评估人格特质，对主要抑郁治疗结果（未缓解、无反应和抵抗）进行探索性研究。
在 6 项欧洲研究中，共招募了 743 名心境障碍患者（455 例 MDD（61.24%）和 288 例 BD（38.76%））。为了检验 TCI 维度对治疗结果的影响，我们采用广义逻辑模型，考虑了年龄、性别和教育等可能的混杂因素。还对共病（焦虑和物质使用障碍）进行了阳性结果的控制。
MDD 未缓解者表现出高的回避（HA）和自我超越（ST）（p=0.0004，d=0.40；p=0.007，d=0.36）和低的坚持（P）和自我指导（SD）（p=0.05；d=0.18；p=0.002，d=0.40）；MDD 无反应者表现出略有不同的特征，表现为高 HA 和低的奖赏依赖（RD）和 SD；最后，MDD 抵抗者表现出低 RD、P 和合作性（C）。在 BD 患者中，仅观察到无反应者 HA 较高。
回顾性横断面设计、TCI 评估不考虑心境状态以及双相患者数量较少是主要局限性。
特定的 TCI 人格特质与 MDD 患者的抑郁治疗结果相关。将这些人格特质与其他社会人口统计学和临床预测因素相结合，可以提高目前可用的预测模型的准确性。
