Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki 036–8562, Japan.
J Affect Disord. 2011 Dec;135(1-3):321-5. doi: 10.1016/j.jad.2011.06.050. Epub 2011 Jul 23.
Determining the factors that predict antidepressant response and offering suitable treatments to people who suffer from major depressive disorder (MDD) is important. We investigated the personality factors that influence paroxetine treatment response by dividing antidepressant responders into two groups.
We treated 93 patients with MDD using 40 mg/day of paroxetine for six weeks. We used the Cloninger's Temperament and Character Inventory (TCI) to evaluate each participant's personality before the treatment. Of the 93 patients, 75 completed the protocol. The Montgomery Asberg Depression Rating Scale (MADRS) was used to evaluate depressive symptoms before the treatment and at one-, two-, four-, and six-week intervals. We divided the patients into four groups: later responders (LRs), early responders (ERs), nonresponders (NRs), and dropouts (DOs).
Compared with 91 normal control participants, patients with MDD had less novelty seeking and self-directedness and greater harm avoidance. ERs showed less harm avoidance and more self-directedness than the other groups. LRs' TCI scores did not differ from the other groups.
These results suggest that ERs' personality characteristics are different from those of other patients with MDD and that evaluating patients' personality using the TCI at baseline may predict their antidepressant response.
Our sample of patients with MDD was small. Some of the patients with severe MDD had difficulty completing the TCI.
确定预测抗抑郁药反应的因素，并为患有重度抑郁症（MDD）的人提供合适的治疗方法非常重要。我们通过将抗抑郁药应答者分为两组来研究影响帕罗西汀治疗反应的人格因素。
我们使用 40mg/天的帕罗西汀治疗 93 名 MDD 患者，为期六周。在治疗前，我们使用 Cloninger 的气质与性格量表（TCI）评估每个参与者的人格。在 93 名患者中，有 75 名完成了方案。使用蒙哥马利抑郁评定量表（MADRS）在治疗前以及治疗后 1、2、4 和 6 周评估抑郁症状。我们将患者分为四组：迟应答者（LRs）、早应答者（ERs）、无应答者（NRs）和脱落者（DOs）。
与 91 名正常对照参与者相比，MDD 患者的新奇寻求和自我导向性较低，而回避伤害性较高。ERs 的回避伤害性低于其他组，自我导向性高于其他组。LRs 的 TCI 评分与其他组无差异。
这些结果表明，ERs 的人格特征与其他 MDD 患者不同，使用 TCI 在基线评估患者的人格可能预测其抗抑郁药反应。
我们的 MDD 患者样本较小。一些患有重度 MDD 的患者在完成 TCI 时遇到困难。
