Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, One University Place, Rensselaer, NY 12144, USA.
Reprod Toxicol. 2011 Feb;31(2):158-63. doi: 10.1016/j.reprotox.2010.09.013. Epub 2010 Oct 8.
Trace exposures to metals may affect female reproductive health. To assess the relation between trace concentrations of blood metals and female fecundity, 99 non-pregnant women discontinuing contraception for the purpose of becoming pregnant were prospectively followed. Participants completed a baseline interview and daily diaries until pregnant, or up to 12 menstrual cycles at risk for pregnancy; home pregnancy test kits were used. For 80 women, whole blood specimens were analyzed for arsenic, cadmium, lead, magnesium, nickel, selenium and zinc using inductively coupled plasma mass spectrometry (ICP-MS). Time to pregnancy was estimated using Cox proportional hazards models for discrete time. Metal concentrations were generally within population reference intervals. Adjusted models suggest a 51.5% increase in the probability for pregnancy per 3.60 μg/L increase in Mg (P=0.062), and a 27.7% decrease per 0.54 μg/L increase in Zn (P=0.114). Findings indicate that Mg and Zn may impact female fecundity, but in varying directions.
痕量金属暴露可能会影响女性生殖健康。为了评估血液中痕量金属浓度与女性生育能力之间的关系，99 名正在避孕以准备怀孕的非孕妇前瞻性随访。参与者完成基线访谈和每日日记，直到怀孕，或怀孕风险 12 个月经周期；使用家庭妊娠测试套件。对于 80 名女性，使用电感耦合等离子体质谱法（ICP-MS）分析全血样本中的砷、镉、铅、镁、镍、硒和锌。使用 Cox 比例风险模型估计怀孕时间，用于离散时间。金属浓度通常在人群参考区间内。调整后的模型表明，Mg 每增加 3.60μg/L，怀孕的概率增加 51.5%（P=0.062），Zn 每增加 0.54μg/L，怀孕的概率降低 27.7%（P=0.114）。研究结果表明，Mg 和 Zn 可能会影响女性生育能力，但影响方向不同。
