Huntington Medical Research Institutes, Pasadena, CA, United States.
J Magn Reson. 2010 Dec;207(2):352-5. doi: 10.1016/j.jmr.2010.09.010. Epub 2010 Sep 22.
We demonstrate a robust procedure for the quantitative characterization of glial metabolism in human brain. In the past, the slope of the uptake and production of enriched label at steady state were used to determine metabolic rates, requiring the patient to be in the magnet for 120-160 min. In the present method, (13)C cerebral metabolite profiles were acquired at steady state alone on a routine clinical MR scanner in 25.6 min. Results obtained from the new short method (SAGA) were comparable to those achieved in a conventional, long method and effective for determination of glial metabolic rate in posterior-parietal and frontal brain regions.
我们展示了一种用于定量描述人脑神经胶质代谢的稳健方法。在过去，采用稳态下富集标记的摄取和生成斜率来确定代谢率，这要求患者在磁体中停留 120-160 分钟。在本方法中，仅在常规临床磁共振扫描仪上以稳态采集（13）C 脑代谢物谱，耗时 25.6 分钟。新的短方法（SAGA）得到的结果与传统的长方法相当，并且可有效确定后顶叶和额叶脑区的神经胶质代谢率。
