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缰核对于斑马鱼依赖经验的恐惧反应的修饰至关重要。

The habenula is crucial for experience-dependent modification of fear responses in zebrafish.

机构信息

RIKEN Brain Science Institute, Wako, Saitama, Japan.

出版信息

Nat Neurosci. 2010 Nov;13(11):1354-6. doi: 10.1038/nn.2654. Epub 2010 Oct 10.

DOI:10.1038/nn.2654
PMID:20935642
Abstract

The zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is equivalent to the mammalian medial habenula. Genetic inactivation of the lateral subnucleus of dHb (dHbL) biased fish towards freezing rather than the normal flight response to a conditioned fear stimulus, suggesting that the dHbL-IPN pathway is important for controlling experience-dependent modification of fear responses.

摘要

斑马鱼背侧缰核（dHb）与脚间核（IPN）的连接存在明显的不对称性，与哺乳动物的内侧缰核相当。dHb 外侧亚核（dHbL）的基因失活使鱼偏向于冻结而不是对条件性恐惧刺激的正常飞行反应，这表明 dHbL-IPN 通路对于控制恐惧反应的经验依赖性修饰很重要。

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本文引用的文献

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The habenula: from stress evasion to value-based decision-making.缰核：从逃避压力到基于价值的决策。
Nat Rev Neurosci. 2010 Jul;11(7):503-13. doi: 10.1038/nrn2866.
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Identification of the zebrafish ventral habenula as a homolog of the mammalian lateral habenula.鉴定斑马鱼腹侧缰核作为哺乳动物外侧缰核的同源物。
J Neurosci. 2010 Jan 27;30(4):1566-74. doi: 10.1523/JNEUROSCI.3690-09.2010.
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